Proteins that nestle within the membranes of cells in our body are vitally important. Such ‘membrane proteins’ are essential for cellular function; for example, they control cell-to-cell communication, hormone action and the transport of materials between cells. Investigating how these proteins function may lead to new treatments for diseases like depression, anxiety, cardiovascular disease, inflammatory disease and cancer. We focus on a number of membrane transporters that play a role in the Innate Immune system. These proteins are upregulated in macrophages in response to bacterial infection. Potentially, this could lead to more effective therapies to treat immune and inflammatory diseases.